Spironolactone Side Effects

Spironolactone is associated with a range of side effects, which can be grouped into common, less common, and serious categories.[1]

Common side effects may include:

  • Dizziness or feeling lightheaded[1][2][3][4][7]
  • Nausea and vomiting[1][2][3][4][5][6][7]
  • Diarrhea and abdominal cramps[2][3][4][5][7]
  • Headache[3][4][5][8]
  • Fatigue or unusual tiredness[1][5][8]
  • Muscle cramps, especially in the legs[1][5][6]
  • Increased urination (polyuria)[5]
  • Breast tenderness or swelling (can occur in both males and females)[3][4][5][6]
  • Irregular menstrual cycles or bleeding after menopause[2][3][5]
  • Reduced sex drive (decreased libido)[3][5][6][8]
  • Drowsiness[2][3][4][8]

Less common or uncommon side effects can include:

  • Confusion[3][4][5][8]
  • Restlessness[1]
  • Skin rash or itching[1][5][6][8]
  • Hair loss or thinning[6]
  • Erectile dysfunction[5][6]
  • Pain in nipples[6]
  • Sores, welts, or blisters[6]

Serious side effects (require immediate medical attention):

  • Severe allergic reactions (swelling of the face, lips, mouth, tongue or throat, difficulty breathing, hives, rash, fever, joint pain)[1][6]
  • High potassium levels (hyperkalemia), which can cause muscle weakness, irregular heartbeat, or numbness/tingling in extremities[2][4][5][6]
  • Dehydration and low sodium (hyponatremia)[1][4][5]
  • Worsening kidney function or acute kidney injury[1][4][5]
  • Stomach bleeding or ulcers[5][6]
  • Loss of balance or coordination[5][8]
  • Chest pain or shortness of breath (rare)[6]

If you experience severe side effects or signs of an allergic reaction, seek medical attention immediately. For a comprehensive list, consult your doctor or review the leaflet provided with your medication.[1][6][7]

References

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