Side Effects

Tamoltra Side Effects

Tamoltra—which contains tramadol and paracetamol—is used for the treatment of moderate to moderately severe pain in adults[4]. Like all medications, it can cause side effects. These range from common to rare, and some can be serious.

Common side effects of Tamoltra (tramadol-containing medicine) include:

  • Loss of appetite, anxiety, confusion, sleep disorders, mood changes (such as nervousness or feeling high-spirited)[1]
  • Dizziness, drowsiness, headache, shaking[1]
  • Nausea, vomiting, digestive issues (constipation, flatulence, diarrhea, stomach pain or discomfort, dry mouth)[1][5]
  • Skin rash, increased sweating, dermatitis (itchy, dry skin or a rash on swollen, reddened skin)[1][5]
  • Abnormal physical weakness or lack of energy, fatigue[1][5]
  • Itchiness, vertigo, heartburn[5]

Less frequent or rare side effects can include:

  • Anemia (e.g., pale skin, tiredness, dizziness, shortness of breath)[1]
  • Neutropenia or agranulocytosis (signs of infection such as sore throat, fever, chills)[1]
  • Thrombocytopenia (bleeding from gums/nose, blood in urine/stool, easy/excessive bruising)[1]
  • Weight loss, depression, nightmares, memory lapses, hallucinations, mood changes, changes in perception/activity[1][5][7]
  • Impaired male sexual function (inability to achieve erection/orgasm)[1]
  • Uncoordinated movements, seizures/fits, tingling, numbness, migraine, muscle twitching, slurred speech[1][6][7]
  • Blurred vision, miosis (constricted pupils), mydriasis (dilated pupils), ringing or buzzing in the ears[1][3]
  • Difficulty breathing (dyspnea), difficulty swallowing, blood in stools[1][7]
  • Abnormal liver or urine test results[1]
  • Difficulty or pain on passing urine[1][3]

Serious risks include:

  • Allergic reactions such as swelling of lips, mouth, throat, or tongue; rash that is swollen, raised, itchy, blistered, or peeling; or breathing difficulties (possible signs of anaphylaxis; seek emergency care)[7]
  • Seizures, especially in those with a history of seizures or when taken with other medicines that lower seizure threshold[3][6][7]
  • Serotonin syndrome (risk increases if taken with other serotonergic drugs), presenting as confusion, shivering, sweating, high fever, muscle rigidity, and seizures[2][5][6]
  • Breathing problems, especially at high doses or in combination with other depressants[2][3][7]
  • Dependence, tolerance, and withdrawal symptoms upon abrupt discontinuation (e.g., anxiety, panic attacks, hallucinations, paraesthesia)[1][8]

References

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