Rifafour Side Effects

Rifafour is a fixed-dose combination medication used for the treatment of tuberculosis (TB), containing rifampicin, isoniazid, pyrazinamide, and ethambutol. Since it includes multiple active ingredients, side effects may result from any single component or their combined use^[2].

Common side effects of Rifafour (and its individual components) include:

Nausea, vomiting, diarrhea, and upset stomach^[1][7]
Loss of appetite and stomach cramps or pain^[1][7]
Dizziness, drowsiness, fatigue, and headache^[5][7]
Heartburn, bloating, and belching^[7]
Orange or red discoloration of body fluids such as urine, saliva, sweat, and tears (harmless, but can stain contact lenses or dentures)^[1][3][7]
Changes to menstrual cycle^[7]

Serious side effects that may require urgent medical attention include:

Liver dysfunction, hepatitis, jaundice, and yellowing of the skin or eyes^[3][4][5][6]
Severe allergic reactions (e.g., swelling of the face or throat, difficulty breathing, hives)^[5][3]
Vision problems, including changes in color vision, blurred vision, or optic neuritis (mainly due to ethambutol; Rifafour is contraindicated in patients with optic neuritis)^[4][5][6]
Abnormal blood clotting, unusual bleeding or bruising, and blood disorders^[3][5][7]
Inflammation of the pancreas (pancreatitis), causing severe abdominal and back pain^[5]
Mental confusion, agitation, mood changes or depression^[3]
Kidney problems, such as dark urine or changes in urination^[3]
Skin rash, itching, or other severe skin reactions^[3][5][7]

Contraindications & Cautions: Rifafour should not be used in individuals with hypersensitivity to any of its components, active liver disease or jaundice, prior optic neuritis, porphyria, or children under 13 years old. Caution should also be exercised regarding potential drug interactions and monitoring for side effects^[4][5][6].

References

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