Common side effects of misoprostol include:
- Diarrhea
- Stomach pain or cramps
- Nausea
- Abdominal pain and cramping
- Heavy vaginal bleeding (especially when used for abortion or miscarriage)
- Passing large blood clots and pregnancy tissue (when used for pregnancy termination)
These side effects most frequently occur within the first few weeks of treatment. Diarrhea and stomach cramps are particularly common, and may resolve as your body adjusts to the medication[1][3].
Serious side effects can happen but are less common. These may include:
- Severe diarrhea leading to dehydration
- Severe or persistent abdominal pain
- Heavy bleeding that requires medical attention or surgery
- Incomplete abortion
- Serious infection
- Blood clots in the uterus
- Allergic reactions (such as swelling, trouble breathing, hives, or rash)
If you experience any symptoms of a severe allergic reaction—including difficulty breathing, swelling of the face or throat, severe dizziness, or a widespread skin rash—seek emergency medical help immediately[1][5].
Mental and emotional side effects have also been reported. These can include feelings of relief, sadness, or other emotional responses, particularly when misoprostol is used for abortion[7].
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