Ozempic (semaglutide) is a medication commonly prescribed to manage type 2 diabetes and, increasingly, for weight loss. While most side effects are mild and resolve over time, there are specific long-term side effects that patients should be aware of[1].
Potential Long-Term Side Effects of Ozempic:
- Pancreatitis: Ozempic can rarely cause inflammation of the pancreas. Symptoms may include abdominal pain, nausea, vomiting, back pain, and fever. This condition can persist even after stopping the medication[1][2].
- Vision Problems: There is a risk of worsening diabetic retinopathy (eye damage related to diabetes), especially in those who already have eye issues[1][2].
- Kidney Injury: Prolonged vomiting or diarrhea caused by the medication can lead to dehydration and, in rare cases, acute kidney injury. Symptoms may include confusion, fatigue, and decreased urination[1][2].
- Skin Changes: Rapid weight loss from Ozempic can cause sagging skin, sometimes described as “Ozempic face”[1].
- Gallbladder Problems: The medication may increase the risk of gallstones or gallbladder disease[2].
- Thyroid Tumors: Animal studies have shown an increased risk of thyroid tumors, including cancer, leading to a boxed warning by the FDA. While this has not been conclusively proven in humans, monitoring for symptoms such as neck lumps or swelling is recommended[2][6].
Common (usually short-term) Side Effects:
- Nausea (most common, often resolves within weeks[4][5])
- Vomiting
- Diarrhea
- Constipation
- Abdominal pain
- Fatigue
- Indigestion
- Injection site reactions (pain, redness, or itching)
- Dizziness or headache[3]
These effects are most common when starting Ozempic or after a dosage increase and typically subside as the body adjusts[1][3][4][5].
When to Contact a Doctor: Seek medical attention if you experience:
- Severe or persistent vomiting, diarrhea, or abdominal pain
- Yellowing of the skin or eyes
- Sudden changes in vision
- A lump or swelling in the neck
Most people tolerate Ozempic well, but all medications carry risks. Discuss any ongoing, bothersome, or severe side effects with your healthcare provider for proper evaluation and management[3].
References
- [1] What are the long-term side effects of Ozempic? – Drugs.com
- [2] Ozempic long term side effects – Medical News Today
- [3] Ozempic Side Effects – WebMD
- [4] Ozempic Side Effects: Understanding the Risks and Symptoms
- [5] The Long-term Safety of Ozempic: What You Need to Know
- [6] Possible Side Effects of Ozempic ® (semaglutide) Injection