Arthraway is commonly understood to refer to glucosamine-based supplements used for chronic arthritis management. The side effects associated with chronic use of glucosamine, and similar arthritis pain relief medications, are generally considered mild but can become more significant in specific populations or with long-term use[3][4].
Common chronic side effects may include:
- Nausea[1][2][3]
- Heartburn[3]
- Diarrhea[2][3]
- Constipation[2][3][4]
- Headache[1][4]
- Edema (swelling due to fluid retention, particularly with NSAIDs)[1]
- Rashes or skin reactions[3][4]
- Anemia (especially with long-term NSAID or DMARD use)[1]
Other less frequent or serious effects include:
- Drowsiness[3]
- Allergic reactions (especially in those with shellfish allergies, as many glucosamine products are derived from shellfish)[3][4]
- Potential worsening of asthma[3]
- Potential increase in eye pressure in people with glaucoma (consult your doctor if you have glaucoma)[3]
- Rare genitourinary symptoms such as decreased urine output (oliguria)[2]
Risk factors for more severe side effects include older age, pre-existing conditions (like diabetes or chronic lung disease), and combined use with other medications such as corticosteroids or anticoagulants, which may increase the risk of infection or bleeding[5].
Interactions can occur with other drugs:
- Acetaminophen: May reduce effectiveness when used with glucosamine[3]
- Warfarin: Increased bleeding risk when combined with glucosamine (alone or with chondroitin)[3]
- Anti-diabetic medications: Glucosamine may elevate blood sugar levels, requiring monitoring[4]
Most side effects from glucosamine and related arthritis medications are reported as mild and infrequent, with the frequency not differing significantly from placebo in long-term trials[4].
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