Yasmin (drospirenone and ethinyl estradiol) is a combined oral contraceptive that can cause several long-term side effects. While many users tolerate Yasmin well, there are significant risks and side effects documented with extended use.
- Increased risk of blood clots: Yasmin, like other combined oral contraceptives, increases the risk of deep vein thrombosis, pulmonary embolism, heart attack, and stroke. The risk is especially high during the first year of use and upon restarting after a break. Smoking, age over 35, and other health conditions further elevate this risk[2][5][7].
- High blood pressure: Some users may develop high blood pressure over time[1][6].
- Breast cancer: Studies show a modest (about 20%) increased risk of breast cancer among current and recent users, with risk climbing the longer oral contraceptives are used[4].
- Cervical cancer: Long-term use (over 5 years) may increase the risk of cervical cancer, with risk rising the longer Yasmin is taken. However, this risk diminishes after discontinuing the pill[4][5].
- Other cancers: On the positive side, Yasmin use is associated with a reduced risk of endometrial cancer, with the protective effect lasting for many years after stopping[4].
- Liver issues: Long-term use can rarely cause liver disease or tumors, and symptoms such as jaundice (yellowing of the skin or eyes) should be reported to a doctor[3][5].
- Mood changes and depression: Some users experience mood changes, depression, or irritability [3].
- Eye problems and vision changes: Rarely, serious eye symptoms including loss of vision or blurred vision may occur[3].
- Other possible effects: Other long-term side effects reported include breast tenderness, headaches or migraines, nausea, lower back pain, hair loss, and changes in menstrual bleeding patterns[1][2][3].
The decision to use Yasmin long-term should be made with a healthcare provider, weighing the benefits against the risks, especially for those with pre-existing risk factors such as smoking, high blood pressure, or a personal or family history of blood clots or hormone-related cancers.
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