Macropen 500 (macrolide antibiotic, also known as midecamycin) may cause a variety of side effects. Some of these side effects can be serious and require urgent medical attention.
- Skin reactions, such as rashes or lesions (Jarisch-Herxheimer reaction)
- Cloudy, foamy, or bad-smelling urine, increased need to urinate (crystalluria)
- Painful throat
- Premature destruction of red blood cells (haemolytic anaemia), leading to pale skin, weakness, or breathlessness
- Fever, chills, swelling, sore throat, and fatigue, which could indicate a low white blood cell count (leukopenia, agranulocytosis)
- Unusual or unexplained bruising or bleeding due to low blood platelets (thrombocytopenia)
- Painful, stiff neck with limited range of motion and high fever (aseptic meningitis)
- Convulsions (fits)
- Stomach pain and cramping, loss of appetite, nausea, vomiting, swollen stomach, diarrhea (possibly with pus or mucus in stool), tiredness, fever, dry mouth, and feeling extremely thirsty
- Yellowing of the skin and eyes, dark urine, and light coloured stools (jaundice)
- Changes in urination, blood in the urine, swelling (interstitial nephritis)
These are considered serious side effects and may require urgent medical attention.[1]
Other side effects include:
- Headache (frequent)
- Fungal infections of the skin, nails, mouth, throat, or vagina (less frequent)
- Increased bleeding time when injured
- Excessive involuntary movements (hyperkinesia), distractibility, inability to focus (hyperactivity), dizziness
If you experience any of the symptoms mentioned above, consult your doctor as soon as possible.[1]
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