Testosterone cypionate can cause a range of side effects, which may be mild or serious. Common side effects include acne, injection site pain and swelling, increased hair growth, development of breast tissue in men (gynecomastia), more frequent or longer-lasting erections, mood changes, headaches, and decreased sperm count at high doses[1].
Other reported side effects are increased blood pressure, headache, increased red blood cell levels, weight gain, irritability, mood swings, trouble sleeping, muscle pain, fluid retention, pain or redness at the injection site, enlarged prostate, tiredness, and digestive issues like nausea or heartburn[5].
Serious side effects can include:
- Heart attack, heart failure, stroke, or blood clots[1][3]
- Liver damage—signs include stomach pain, yellowing of the skin or eyes, dark urine, or light-colored stools[3]
- Blockage of the urinary tract, especially in those with enlarged prostate (benign prostatic hyperplasia), causing pain or urinary issues[3]
- Swelling of arms or legs, sudden weight gain (fluid retention)[3]
- Decreased sperm production and infertility[2][5]
- Enlarged breasts in men[5]
- Mood disorders such as depression, psychosis, hallucinations, and suicidal thoughts[1][3][7]
- Rare but serious: sudden chest pain, shortness of breath, severe headaches, speech difficulties, or sudden weakness (possible signs of stroke or heart attack)[7]
People with a history of heart, liver, kidney problems, or prostate issues are at higher risk for adverse events, especially with high doses or long-term use[3]. Women, children, and pregnant individuals should not use testosterone cypionate due to risk of virilization and other serious side effects[6].
If you experience any severe, persistent, or concerning side effects while using testosterone cypionate, you should contact your healthcare provider immediately.
References
- [1] Testosterone Cypionate: Side Effects, Dosage, Uses, and More – Healthline
- [2] Testosterone cypionate – Wikipedia
- [3] Testosterone cypionate (Depo-Testosterone) – GoodRx
- [5] Testosterone (Depo-Testosterone, Xyosted, and others) – Uses, Side … – WebMD
- [6] Testosterone Cypionate: Package Insert / Prescribing Info – Drugs.com
- [7] Testosterone Side Effects: Common, Severe, Long Term – Drugs.com
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