Telatri is a generic, fixed-dose combination HIV medication containing tenofovir disoproxil fumarate, lamivudine, and dolutegravir, widely used in antiretroviral therapy (ART)[4][6]. Like all HIV medications, Telatri has potential side effects—most are mild and temporary, while some can be serious or long-lasting.
Common side effects associated with Telatri or its components include:
- Nausea
- Diarrhea
- Headache
- Feeling tired (fatigue)
- Sleep disturbances (trouble falling or staying asleep)
- Rash
- Mood changes
- Loss of appetite
- Dizziness
- Mild liver enzyme changes seen on blood tests
These side effects often occur during the first few weeks after starting therapy and usually resolve as the body adjusts[1][3][5].
Less frequent but potentially serious side effects include:
- Neuropathy (pain or tingling in hands and feet)
- Pancreatitis
- Kidney problems
- Liver problems
- Changes in bone density
- Abnormal blood cell counts
- Lactic acidosis (build-up of lactic acid in the blood)
- Allergic (hypersensitivity) reactions, particularly with dolutegravir[3][5][7]
- Symptoms can include rash, fever, swelling, trouble breathing, or severe skin reactions.
- Immediate medical attention is required if these occur.
Some longer-term risks of combination HIV therapy (including Telatri) may include:
- Bone loss (osteopenia/osteoporosis)
- Changes to body fat distribution
- Increased cholesterol or triglycerides
- Increased risk of heart disease
- Metabolic changes (such as high blood sugar and risk of diabetes)
Serious side effects (especially allergic reactions) are rare, but you should contact your healthcare provider immediately if you experience difficulty breathing, severe rash, swelling of the face or throat, or jaundice (yellowing of the skin/eyes)[7].
Regular monitoring and open communication with your healthcare team are important for managing and minimizing side effects. If you experience persistent or severe side effects, do not stop your medication without medical advice[1].
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