Semaglutide Weight Loss Side Effects

Semaglutide weight loss side effects most commonly include gastrointestinal symptoms such as nausea, vomiting, diarrhea, constipation, abdominal pain, and gas. Understanding these side effects is crucial for those considering semaglutide as part of their weight loss journey.

Common Semaglutide Weight Loss Side Effects

Gastrointestinal Symptoms

• Nausea: Reported in 16% to 44% of users, nausea is often most intense during the initial phase of treatment. This can generally subside as the body adjusts to the medication (Pharmko; GoodRx).
• Vomiting: Experienced by up to 24% of patients, vomiting is typically related to slowed digestion, which can contribute to dehydration (Pharmko).
• Diarrhea: Affecting 8% to 30% of patients, persistent diarrhea can lead to dehydration and kidney issues (Pharmko; Ozempic).
• Constipation: Occurs in 5% to 25% of users and may last for weeks as the digestive system adapts (Pharmko).
• Abdominal Pain: Spotted in up to 20% of patients, this discomfort may sometimes signal serious conditions like pancreatitis (Pharmko; GoodRx).
• Gas and Bloating: Burping, acid reflux, and stomach distension are common, particularly early in the treatment phase (GoodRx; UCLA Health).

Other Common Issues

• Fatigue and Dizziness: Some patients experience tiredness or dizziness, possibly due to reduced appetite, dehydration, or rapid weight loss (Stony Brook Medicine; UCLA Health).
• Headache: Although less common than gastrointestinal complaints, headaches are noted by some users (GoodRx).
• Decreased Appetite: While often viewed as a positive for weight loss, this can also lead to fatigue (GoodRx).

Serious Side Effects to Watch For

Noteworthy Risks

• Pancreatitis: Severe abdominal pain accompanied by nausea and vomiting may be signs requiring immediate medical intervention (Pharmko; Stony Brook Medicine).
• Kidney Problems: Damage from dehydration due to vomiting and diarrhea can occur, marked by swelling and changes in urination (Pharmko; Ozempic).
• Gallbladder Issues: Symptoms such as severe upper abdominal pain and jaundice may indicate gallbladder disease (Pharmko; UCLA Health).
• Thyroid Tumors: Though the risk in humans is unconfirmed, animal studies have shown potential for thyroid tumors, prompting an FDA boxed warning.
• Vision Changes: Rapid blood sugar improvements can cause complications such as diabetic retinopathy (Stony Brook Medicine).
• Severe Allergic Reactions: Emergency care is needed for reactions like swelling, difficulty breathing, and rash (Stony Brook Medicine; Within Health).
• Severe Hypoglycemia: This risk increases if taken with other diabetes medications (Stony Brook Medicine).
• Increased Heart Rate: Some patients experience this effect, requiring further monitoring (Stony Brook Medicine).
• Intestinal Blockage: Though rare, symptoms like severe constipation or vomiting could indicate a blockage (GoodRx).

Managing Side Effects

Most side effects diminish as the body adjusts to semaglutide, especially when starting at a low dose and gradually increasing. Maintaining hydration, consuming bland foods, and regular follow-ups with healthcare providers can help manage side effects and detect serious complications early. Understanding and identifying these semaglutide weight loss side effects can prepare users for a safer, more informed weight loss journey.