Polygynax may cause several side effects, although most are generally rare or mild. Commonly reported side effects include:
- Hypersensitivity reactions
- Allergic reactions (such as rash, urticaria, anaphylactic reaction)
- Vaginal burning, irritation, or itching
- A gritty sensation in the vaginal area
- Redness and oedema (swelling) at the application site
These effects are usually temporary and may disappear as your body adjusts to the medication[1][3][7].
You should stop using Polygynax immediately and consult a healthcare professional if you experience signs of an allergic reaction.
Polygynax is contraindicated for people allergic to any of its components (neomycin, polymyxin B, or nystatin), drugs in the same class, peanut or soybean oil (present as an excipient), as well as for those with kidney failure[3][5][7].
Use during pregnancy or breastfeeding is generally not recommended unless prescribed by a doctor, due to the risk of potential systemic absorption and toxicity, particularly ototoxicity (hearing-related side effects) associated with neomycin[7].
Using Polygynax in combination with local spermicides or barrier contraceptives (like latex condoms or diaphragms) is not advised, as it may reduce contraceptive effectiveness or cause device failure[3][5][7].
In cases of prolonged use or overdose, there is a risk of systemic effects, including possible hearing function impairment, particularly in patients with kidney problems[5].