Ostarine, a selective androgen receptor modulator (SARM), has been associated with a range of side effects affecting multiple organ systems and physiological functions, particularly when used in high doses or without medical oversight[1].
Short-term side effects may include:
- Headaches
- Nausea
- Fatigue
- Mood instability or irritability
- Joint discomfort
[1]
Long-term risks include:
- Suppression of luteinizing hormone and testosterone, leading to reduced or halted production of natural hormones and potential sexual dysfunction (e.g., decreased libido, performance issues, testicular shrinkage)
- Liver toxicity and potential for liver damage or drug-induced liver injury
- Mood disorders, with increased risk of anxiety or depression
- Cardiovascular strain, including changes in lipid profiles such as decreased HDL, increased cholesterol, and heart stress
- Increased risk of heart attack or stroke
- Infertility
- Withdrawal symptoms when stopping the drug abruptly, such as low mood, fatigue, and sexual dysfunction
[1][2][3][4][5][6]
Specific reports and clinical trials have documented cases of liver injury associated with ostarine, sometimes resembling the pattern seen with anabolic steroid-induced liver damage[3]. Dose-dependent elevations in liver enzymes (such as ALT and AST) and changes in lipid panels (e.g., decreased HDL, increased cholesterol) have also been observed in clinical studies[2][4]. Adverse psychological effects, including mood swings, anxiety, and even psychosis or hallucinations, have also been described[2][6].
The FDA and multiple health organizations emphasize that ostarine is not FDA-approved for any use in humans and warn of its association with serious or life-threatening events, particularly among teenagers and young adults. These include acute liver failure, heart attack, infertility, menstrual irregularities, sleep disturbances, and other severe outcomes[5][6]. Ostarine is also banned by the World Anti-Doping Agency (WADA) and carries significant risk for athletes[7].
References
- [1] Ostarine Side Effects | Diamond Behavioral Health
- [2] Systematic Review of Safety of Selective Androgen Receptor Modulators (SARMs)
- [3] Drug-Induced Liver Injury From Enobosarm (Ostarine), a Selective Androgen Receptor Modulator
- [4] Effects of Ostarine and Endurance Training on Some Functional and Biochemical Indicators
- [5] Ostarine – Uses, Side Effects, and More | WebMD
- [6] FDA Warns of Use of Selective Androgen Receptor Modulators (SARMs) Among Teens, Young Adults
- [7] Athlete Advisory: Growing Evidence that Ostarine is a Risk for Athletes
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