Answer the side-effect intent for cyklokapron without diagnosing; distinguish common from serious reactions and give safe next-step/reporting guidance.

Source

Clinical statements on this page are taken from the SAHPRA-approved patient information leaflet (approved 21/10/2025) and professional information (approved 21/10/2025) for this product: patient information leaflet, professional information. Retrieved 2026-09-03. Where this page and the approved leaflet differ, the leaflet is correct.

What is Cyklokapron?

Which leaflet this comes from

There is no approved leaflet for Cyklokapron in SAHPRA’s public repository. The information below is from the approved leaflet for CYNEX, another South African product containing Tranexamic acid. Products with the same active ingredient can still differ in strength, formulation and approved uses, so check the leaflet in your own pack.

Cyklokapron contains the active ingredient Tranexamic acid.

Active ingredient — Tranexamic acid
Registration number — 43/8.1/0263
Registration holder — Ranbaxy Pharmaceuticals (Pty) Ltd

It is approved for:

Prostate
Bladder surgery

Common side effects of Cyklokapron

Not everyone gets side effects. The effects below are those listed in the South African approved leaflet, grouped using the leaflet’s own frequency wording.

About these frequency terms

This leaflet groups effects as “Frequent” and “Less frequent” rather than the very common/common/uncommon scale used in some other markets.

Frequent side effects

Eye disturbances (such as colour disturbances or blurred vision)
Nausea (feeling sick), vomiting (being sick), diarrhoea

Less frequent side effects

Low blood pressure manifested as light-headedness, dizziness, or even fainting

Frequency unknown side effects

Seizures (convulsions or fits)

Serious side effects and warning signs

This leaflet does not set out a separate list of serious side effects. The general warning signs below apply to any medicine.

General warning signs that apply to any medicine

Call for emergency help now if any of these happen

Difficulty breathing, wheezing, or tightness in the throat or chest
Swelling of the face, lips, tongue or throat
A widespread rash with blistering or peeling skin, or sores in the mouth, eyes or genitals
Fainting, collapse, or a sudden severe drop in alertness
Chest pain, or sudden weakness or numbness on one side of the body
A fit (seizure), or confusion that comes on suddenly

In South Africa call 10177 for an ambulance, or 112 from a mobile phone. Go to your nearest emergency department if it is faster. Do not wait to see whether the symptom settles.

How long can side effects last?

How long a side effect lasts depends on the effect, the product, how long it has been used, and the person. Some effects ease within days as the body adjusts. Others continue for as long as the product is used. A few can persist after stopping, and some need review rather than waiting.

Settling effects — mild effects that ease over the first days or weeks of use
Ongoing effects — effects that continue while the product is being used and improve after stopping
Persistent effects — effects that continue after stopping and need medical review
Delayed effects — effects that appear after weeks or months rather than immediately

Which of these applies to a particular effect is a clinical question. If a side effect is not settling, is getting worse, or is affecting your daily life, that is worth a conversation with a pharmacist or doctor regardless of how long it has been going on.

Evidence required before publish — source the following for Cyklokapron from the SAHPRA-approved patient information leaflet or professional information, and cite what you actually used.

Anything the approved information for Cyklokapron says about how long specific effects last
Whether the source describes any effect as usually temporary, or as needing review if it persists
Whether any effect is described as continuing after the product is stopped

Factors that may affect side effects

The approved leaflet identifies the following cautions and factors.

Do not use it at all if

If you are hypersensitive (allergic) to tranexamic acid or any of the other ingredients of CYNEX 500 mg INJECTION (listed in section 6)
If you have abnormal colour vision
If you experience massive upper urinary tract bleeding
If you have a tendency or a history of developing blood clots
If you have a condition in which a blood clot in a vein causes pain and inflammation (thrombophlebitis)
If you have a condition affecting the ability of your blood to clot and thereby stop bleeding
If you suffer from a liver disorder
If you suffer from an abnormal and very dangerous condition in which blood collects beneath a membrane that covers the brain
If you are pregnant or breastfeeding

Use with care, and tell your doctor, if

If you have a kidney disorder, you should receive lower doses
If you do not know why you suffer from menorrhagia (heavy menstrual bleeding or bleeding that lasts longer than 7 days), the cause for menorrhagia should first be established
If you have had seizures (convulsions or fits)
If you are receiving CYNEX 500 mg INJECTION for a long period of time (you should undergo regular eye examinations)
If you have blood in your urine, it may lead to urinary tract obstruction
If you have ever had any uncontrollable bleeding
If you suffer from excessive clotting or bleeding throughout your body (disseminated intravascular coagulation). Your doctor may carry out a blood test to see if the process that inhibits blood clotting (called fibrinolysis) is activated
If you are at risk of having blood clots. Please consult your doctor, even if these statements were applicable to you at any time in the past. Children and adolescents Do not give CYNEX 500 mg Injection to children because data on efficacy and safety is limited

Pregnancy and breastfeeding

If you are pregnant or breastfeeding, think you may be pregnant or are planning to have a baby, please consult your doctor, pharmacist or other health care provider for advice before receiving You should not receive CYNEX 500 mg INJECTION if you are pregnant or breastfeeding

Interactions and medicines to check

The approved leaflet names these interactions.

Medicines that help blood to clot, such as antifibrinolytic medicines
Thrombolytic medicines (medicines that prevent blood clotting) may oppose the action of CYNEX 500 mg INJECTION
Certain hormones (oestrogens) may increase the potential for developing blood clots

Bring the actual products to the conversation

A pharmacist can check for interactions much faster from the packaging than from remembered names.

What to do if you experience side effects

If you think you are having a side effect, the response depends on how severe it is. Use the warning signs above first — if any of those apply, treat it as urgent.

If the symptom is severe or frightening

Get medical help immediately. Call 10177 for an ambulance, or 112 from a mobile phone, or go to the nearest emergency department. Take the product and its packaging with you if you can.

If the symptom is mild but bothering you

Write down what the symptom is, when it started, and how it relates to when you take the product
Check the leaflet that came with the product to see whether the symptom is listed
Speak to your pharmacist — for many questions this is the fastest route to a useful answer
Contact the prescriber if the symptom is affecting your daily life or is not settling

Do not stop a prescribed treatment on your own

Stopping some treatments suddenly causes its own problems, and the condition being treated may get worse. If you want to stop, ask a pharmacist or doctor how to do it safely — they can usually offer an alternative.

You can also report a suspected side effect in South Africa. Reporting does not replace getting medical advice, and you do not need to be certain the product was the cause.

When to seek urgent medical help

Some symptoms need medical attention straight away rather than an appointment in a few days. Do not wait to see whether they settle.

Call for emergency help now if any of these happen

Difficulty breathing, wheezing, or tightness in the throat or chest
Swelling of the face, lips, tongue or throat
A widespread rash with blistering or peeling skin, or sores in the mouth, eyes or genitals
Fainting, collapse, or a sudden severe drop in alertness
Chest pain, or sudden weakness or numbness on one side of the body
A fit (seizure), or confusion that comes on suddenly

In South Africa call 10177 for an ambulance, or 112 from a mobile phone. Go to your nearest emergency department if it is faster. Do not wait to see whether the symptom settles.

Get same-day medical advice if you have

A high fever, or a rash together with feeling generally unwell
Yellowing of the eyes or skin, or unusually dark urine
Unusual bruising or bleeding that you cannot explain
Severe or persistent vomiting or diarrhoea, especially if you cannot keep fluids down
A sudden change in mood, or thoughts of harming yourself
Any symptom that is rapidly getting worse

If you are having thoughts of harming yourself

Help is available in South Africa. The SADAG helpline is 0800 567 567, or you can go to your nearest emergency department. You do not have to wait until it feels like an emergency.

How to report a suspected side effect in South Africa

South Africa has an official system for reporting suspected side effects, run by the South African Health Products Regulatory Authority (SAHPRA). Reports from the public and from healthcare professionals are how safety signals get detected after a product is already in use.

Who can report

Anyone can report — you do not have to be a healthcare professional, and you do not need to prove that the product caused the problem. A suspicion is enough. Patients, caregivers and family members can all submit a report.

What to have ready

The name of the product, its strength and form, and the batch number if you have it
Why it was being used, and when it was started and stopped
What the suspected reaction was, when it began, and how long it lasted
Any other medicines, supplements or remedies being used at the same time
Basic details about the person affected — age and sex are usually enough

How to report

SAHPRA accepts adverse reaction reports through its e-Services reporting system and through the Med Safety mobile app. Healthcare professionals can also report through the same routes. Current forms and access points are published on the SAHPRA site.

SAHPRA Health Products Vigilance — the main vigilance and reporting hub
SAHPRA e-Services — current adverse reaction reporting access

Reporting is not a substitute for medical care

If someone is unwell now, get medical help first and report afterwards. Urgent symptoms always take precedence over paperwork.

For a fuller walkthrough see how to report an adverse drug reaction.

minoxidil side effects

← Back to more medicine side effects.

Report a side effect

If you think you have had a side effect, you can report a suspected side effect in South Africa. Report a suspected side effect through the appropriate SAHPRA pathway where relevant.

Information only

This page gives general medicine-safety information for people in South Africa. It is not a diagnosis and not personalised medical advice. It cannot tell you whether a symptom you are having is caused by a particular product. Speak to a pharmacist or doctor about your own situation, and do not stop or change a prescribed treatment on the basis of a web page.

Editorial status: draft — not for publication

Brief SE-00391 · build rank 391 · Phase 2 · Tier 2. Every evidence slot on this page must be completed from the SAHPRA-approved source and the page signed off by a qualified clinical or pharmacy reviewer before it is published. Target length 1,300–2,000 words.

Cyklokapron Side Effects