Side Effects

Ketamine Infusion Side Effects

Common short-term side effects of ketamine infusion therapy include nausea, dizziness, dissociation (a trance-like or “out of body” feeling), increased blood pressure, sedation, fatigue, and lightheadedness.[1] These effects are generally temporary and usually resolve within a few hours after treatment.[1][6]

Mental and neurological side effects can include hallucinations, vivid dreams or nightmares, altered perceptions, anxiety, euphoria, blurred or double vision, headache, and brief changes in motor skill/coordination.[3][5][6] Some people may also experience intense excitement or a feeling of intoxication.[3][6]

Serious risks (more common with higher doses or unsupervised use) include respiratory depression, psychiatric events (such as mania or worsening anxiety), increased risk of abuse or misuse, and rare urinary tract or bladder symptoms.[2][3][4] The FDA has issued warnings about compounded or at-home ketamine due to lack of medical monitoring and variation in dosing, which can increase the risk of significant adverse outcomes.[2][4]

Other possible side effects include increased heart rate, increased saliva, feeling drunk or lightheaded, and rash or pain at the injection site.[3][5] Uncommon but notable adverse effects include jerky arm movements, fast eye movements, flashbacks, low mood, suicidal thoughts, delirium, or increased pressure in the eyes.[3]

For most patients, ketamine therapy is considered safe when provided under appropriate medical supervision, with side effects monitored and managed as necessary.[1][6] It is not recommended for individuals with a history of psychosis, substance use disorder, or certain medical conditions without careful evaluation.[6]

References

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