Bovine collagen is generally considered safe for most people when used as directed, but some individuals may experience side effects including gastrointestinal issues such as nausea, flatulence, bloating, constipation, diarrhea, or dyspepsia[8][6]. Minor skin reactions like rashes or acne breakouts, as well as headaches and migraines, have also been reported in some people[1][6].
In rare cases, allergic reactions to bovine collagen are possible, including but not limited to skin inflammation and, very rarely, severe allergic responses (anaphylaxis). Those susceptible to allergies—including to animal products—should exercise caution[5].
Excessive intake of bovine collagen may contribute to liver and kidney problems. For instance, high amounts of collagen can increase the risk of kidney stone formation due to the amino acid hydroxyproline, which the body breaks down into oxalate—a known trigger for kidney stones. Liver fibrosis and, in rare cases, hypercalcemia (an accumulation of calcium possibly causing irregular heart rhythm) have also been noted as potential but uncommon risks with chronic excessive use[1].
Another potential risk, albeit very rare, is the transmission of diseases such as bovine spongiform encephalopathy (BSE) through animal-derived collagen products. This risk appears extremely low in regulated pharmaceutical or supplemental products, but has been recognized in certain contexts (such as surgical implants or unregulated products)[5].
The safety of collagen supplements during pregnancy and breastfeeding has not been sufficiently studied; thus, use should be avoided unless specifically approved by a healthcare provider[7]. Interactions with other medications are generally uncommon, but care should be taken with multi-ingredient supplements, which may include herbs or high-dose vitamins that carry their own risks or might interfere with medical tests[3].
References
- [1] What Are the Side Effects of Taking Collagen? – MedicineNet
- [3] Collagen: Benefits, Side Effects, and More – Healthline
- [5] A Review of the Effects of Collagen Treatment in Clinical … – PMC
- [6] Collagen | Uses, side-effects – Versus Arthritis
- [7] Collagen Peptides – Uses, Side Effects, And More – WebMD
- [8] Evaluation of the Efficacy of a Hydrolyzed Collagen … – PMC
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