ASIC (Alli, orlistat) tablets are associated with several side effects, ranging from mild and common digestive symptoms to rare but serious medical conditions[1][2][3].
Common side effects include:
- Oily or fatty stools
- Loose stools or more frequent bowel movements
- Difficulty controlling bowel movements or urgent need to have a bowel movement
- Oily spotting on underwear or clothing
- Gas with oily discharge
- Stomach pain or discomfort in the rectum
- Headache
- Anxiety
- Irregular menstrual periods
These side effects usually decrease over time but may persist in some users[3][4][6].
Less common or rare side effects:
- Nausea or vomiting
- Body aches, chills, or fever
- Back or side pain
- Dizziness
- Tooth or gum problems
- Rectal pain or discomfort
- Menstrual changes
- Pain during sexual intercourse
- Rash, itching, or hives
If any of these occur, consult your healthcare provider[1][4][5].
Serious side effects (seek immediate medical attention):
- Signs of severe liver injury: itching, yellow eyes or skin (jaundice), dark urine, loss of appetite, or light-colored stools
- Chest tightness, difficulty breathing, or wheezing
- Severe or continuous stomach pain
- Severe abdominal pain (possible sign of pancreatitis or gallbladder problems)
- Kidney-related symptoms: blood in urine, decreased urine output, swelling of legs or feet, painful urination
- Swelling of the face, eyelids, lips, tongue, throat, hands, or feet
- Large, hive-like swelling on body
Rare cases of severe liver injury, kidney stones, gallbladder problems, and severe allergic reactions have been reported. In rare instances, orlistat use has been associated with liver transplant and death, though a definite causal relationship has not been established[2][5][7].
If side effects are severe, persistent, or concerning, stop taking the medication and consult a healthcare provider immediately[2][3].
References
- [1] Alli Side Effects: Common, Severe, Long Term – Drugs.com
- [2] Orlistat: Uses, Side Effects, Interactions, Pictures, Warnings & Dosing – WebMD
- [3] Facts About Alli (Orlistat) for Weight Loss – WebMD
- [4] Orlistat: MedlinePlus Drug Information
- [5] Orlistat (oral route) – Side effects & dosage – Mayo Clinic
- [6] Alli Weight Loss Side Effects – GoodRx
- [7] Completed safety review of Xenical/Alli (orlistat) and severe liver injury – FDA
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