Several prescribed anxiety medications are considered to have fewer side effects for many individuals, though reactions can vary. The following options are frequently noted for their tolerability and relatively low side effect profiles:
- Benzodiazepines (such as Xanax and Valium) are effective and well-tolerated by many, but due to risks of dependency and potential for abuse, they’re generally prescribed short-term or for occasional use[1].
- SSRIs (Selective Serotonin Reuptake Inhibitors) including citalopram (Celexa), sertraline (Zoloft), escitalopram (Lexapro), fluoxetine (Prozac), and paroxetine (Paxil) are popular choices. Among SSRIs, citalopram (Celexa) is notably one of the best-tolerated, with lower risk of weight gain or sexual side effects for many people[1][3][7].
- Bupropion (Wellbutrin) is another option with a relatively low risk for weight gain and sexual side effects, though it’s not a first-line medication for anxiety but may be considered in certain cases[1][3].
- Buspirone (Buspar) is a non-addictive anxiety medication. It targets a specific serotonin receptor subtype, which often results in fewer side effects compared to SSRIs. The most common side effects are mild and may include lightheadedness or nausea[2][4][5].
- Hydroxyzine (Vistaril) is a fast-acting antihistamine that may cause mild sedation, but does not typically cause long-term dependency or significant side effects[4][5].
- Beta-Blockers (such as propranolol and atenolol) are sometimes used to manage the physical symptoms of anxiety, like tremors and rapid heartbeat, especially for performance or situational anxiety, and are well tolerated for most short-term use[2][4][5].
Many physicians will weigh the benefits and side effect profiles of these medications against personal health history and other medications before recommending the best option. For those seeking non-prescription or non-addictive options, lifestyle interventions (exercise, therapy) and natural remedies (such as magnesium or chamomile) may offer benefit for mild cases, but evidence and regulation for supplements can vary[6].
References
- [1] What Is The “Safest” Drug for Anxiety? – Calm Clinic
- [2] What Are Some Alternatives to Benzodiazepines for Anxiety?
- [3] What Is the Best Anxiety Medication with Less Side Effects?
- [4] Exploring Alternatives: Drugs Similar to Xanax Without the Risks
- [5] 5 Non-Addictive Anxiety Medications – Washburn House
- [6] 7 Xanax Alternatives: How Else You Can Help Treat Your Anxiety
- [7] Which SSRIs Have the Least Side Effects? 4 Options – GoodRx