When seeking anxiety pills with the least side effects, it’s important to remember there’s no single “safest” medication suitable for everyone, as responses vary by individual[1]. However, some options are generally better tolerated and have fewer or milder side effects for many people.
- Benzodiazepines (e.g., Xanax, Valium): These are fast-acting and often well tolerated in the short term. They tend to cause fewer side effects initially but can be habit-forming and are not recommended for long-term use due to the risk of dependence and withdrawal. Side effects can include drowsiness and memory issues[1][6].
- SSRIs (Selective Serotonin Reuptake Inhibitors): Certain SSRIs, especially citalopram (Celexa) and escitalopram (Lexapro), have among the lowest risk for significant side effects. They are less likely to cause weight gain and have a favorable profile for many patients. Common mild side effects include nausea, headache, and insomnia, often lessening over time[1][3][7].
- Buspirone (Buspar): This non-addictive option targets a specific serotonin receptor, generally resulting in fewer side effects compared to SSRIs and benzodiazepines. Potential side effects are usually mild, such as lightheadedness and nausea[5].
- Bupropion (Wellbutrin): Although primarily an antidepressant, bupropion is sometimes used for anxiety. It typically causes less weight gain and fewer sexual side effects than other medications in its class[1][3].
- Beta-blockers (e.g., propranolol): These can reduce physical symptoms of anxiety (such as racing heart or shaking) and are non-addictive, but are better for situational or performance-related anxiety rather than chronic anxiety[2][5].
- Gabapentin and Pregabalin: These anticonvulsants can help with anxiety and are also generally well tolerated, though they can cause drowsiness or dizziness in some users[3][8].
- Buspirone and Beta-blockers in combination with therapy are also considered reasonable options, having low risk of dependence and mild side effect profiles when compared to benzodiazepines[5][6].
Some natural or over-the-counter remedies (such as magnesium, chamomile, and L-theanine) are also used for anxiety, though more research is needed to confirm their effectiveness and safety. Always consult with a health professional before starting any supplement, given potential interactions or variability in product quality[4].
References
- [1] What Is The “Safest” Drug for Anxiety? – Calm Clinic
- [2] Alternatives to Benzodiazepines for Anxiety?
- [3] What Is the Best Anxiety Medication with Less Side Effects?
- [4] 7 Xanax Alternatives: How Else You Can Help Treat Your Anxiety
- [5] 5 Non-Addictive Anxiety Medications – Washburn House
- [6] Alternatives to Benzodiazepines for Anxiety: What Works?
- [7] Which SSRIs Have the Least Side Effects? 4 Options – GoodRx
- [8] Non-Addictive Anxiety Medication: Alternatives to Benzodiazepines
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