When considering anxiety medications with the least side effects, it’s important to remember that individual reactions to medications can vary, and what works well for one person may not be appropriate for another[1]. However, certain medications are typically associated with fewer side effects:
- Buspirone (Buspar): A non-addictive medication that targets specific serotonin receptors, leading to a narrower side effect profile. Common side effects are generally mild and include lightheadedness, nausea, and drowsiness[5]. Buspirone does not usually cause sedation or dependence and is considered well-tolerated[1].
- Selective Serotonin Reuptake Inhibitors (SSRIs): SSRIs such as citalopram (Celexa), escitalopram (Lexapro), and sertraline (Zoloft) are commonly prescribed for anxiety and are generally well tolerated, although all SSRIs can potentially cause nausea, headaches, sexual side effects, or insomnia, especially initially[3]. Among SSRIs, citalopram and escitalopram are noted for having some of the least side effects[7].
- Bupropion (Wellbutrin): While not traditionally an anxiety medication, it is sometimes used when there are concerns about sexual side effects and weight gain, as it is less likely to cause these compared to other antidepressants[1][3].
- Beta-blockers such as propranolol: Used primarily for the physical symptoms of anxiety (like rapid heartbeat), beta-blockers generally have a mild side effect profile and are commonly used short-term[5].
- Hydroxyzine (Vistaril): An antihistamine prescribed short-term for anxiety, it is considered non-addictive and has a relatively mild side effect profile, mostly limited to sedation, which may decrease over time[5].
Other options (such as benzodiazepines) are effective for anxiety but have higher risks of sedation, dependence, and withdrawal symptoms, and are therefore not recommended for long-term use or for individuals with a history of substance misuse[1][6].
For those interested in natural or over-the-counter options, supplements like magnesium, L-Theanine, chamomile, and others are sometimes used, but their effectiveness and safety can be inconsistent, and more research is needed. Always consult a healthcare professional before starting any new supplement or medication[4].
References
- [1] What Is The “Safest” Drug for Anxiety? – Calm Clinic
- [3] What Is the Best Anxiety Medication with Less Side Effects?
- [4] 7 Xanax Alternatives: How Else You Can Help Treat Your Anxiety
- [5] 5 Non-Addictive Anxiety Medications – Washburn House
- [6] Alternatives to Benzodiazepines for Anxiety: What Works?
- [7] Which SSRIs Have the Least Side Effects? 4 Options – GoodRx
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