Finding anxiety medications with the least side effects depends on the individual, as everyone reacts differently, but several options are generally considered well-tolerated or come with reduced risk of side effects. One notable group is the Selective Serotonin Reuptake Inhibitors (SSRIs). Among SSRIs, citalopram (Celexa) is frequently cited as causing fewer side effects, with a lower risk of weight gain and sexual side effects compared to other medications. Escitalopram (Lexapro), sertraline (Zoloft), and fluoxetine (Prozac) are also widely used and generally well-tolerated[7].
Other medications with relatively mild side effect profiles include buspirone (BuSpar), a non-benzodiazepine anxiolytic that typically produces only mild side effects like lightheadedness or mild nausea for many patients[5]. Bupropion (Wellbutrin) is another option and stands out because it is less likely to cause weight gain or sexual side effects than many SSRIs, though it is not FDA-approved specifically for anxiety[1][3].
Some non-addictive medications also stand out: hydroxyzine (Vistaril) is a fast-acting antihistamine used for temporary anxiety relief, sometimes causing drowsiness or dry mouth but often considered well-tolerated[5]. Beta-blockers like propranolol, while not traditional anxiolytics, can help relieve the physical symptoms of anxiety (such as rapid heartbeat) without causing significant side effects and without the risk of addiction[2][5].
While benzodiazepines such as Xanax (alprazolam) and Valium (diazepam) are fast-acting and often well-tolerated in the short term, their risk of dependence means they are generally prescribed only for acute, short-term use[1].
Your doctor’s expertise is essential in selecting a medication based on your specific symptoms, health profile, and risk of side effects. Always consult with a healthcare provider for personalized advice before starting or switching anxiety medications.
References
- [1] What Is The “Safest” Drug for Anxiety? – Calm Clinic
- [2] Exploring Alternatives: Drugs Similar to Xanax Without the Risks
- [3] What Is the Best Anxiety Medication with Less Side Effects?
- [5] 5 Non-Addictive Anxiety Medications – Washburn House
- [7] Which SSRIs Have the Least Side Effects? 4 Options – GoodRx
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