When considering anxiety medications with the least side effects, the best option varies based on individual response and the specific type of anxiety. However, certain medications are generally regarded as being better tolerated or having fewer side effects for most people[1].
- Buspirone (Buspar): Widely recognized for causing fewer side effects compared to many other anxiety medications. Buspirone typically results in mild side effects such as lightheadedness, nausea, sore throat, sleep problems, and drowsiness. Because it only targets a specific serotonin receptor subtype, the likelihood of unwanted side effects is lower than with other agents[1][5].
- SSRIs (Selective Serotonin Reuptake Inhibitors): These are often first-line treatments for anxiety. Among SSRIs, Citalopram (Celexa) is often cited as one of the best-tolerated options, with a lower risk of weight gain and sexual side effects for some people[1][3][7]. Other SSRIs like Escitalopram (Lexapro), Sertraline (Zoloft), Paroxetine (Paxil), and Fluoxetine (Prozac) are also commonly prescribed, though their side effect profiles vary slightly.
- Bupropion (Wellbutrin): While primarily an antidepressant, bupropion is sometimes used for anxiety and is less likely to cause weight gain or sexual side effects compared to other medications[1][3].
- Beta-blockers (e.g., Propranolol): These are not traditional anxiety medications but can be helpful in controlling physical symptoms of anxiety (such as rapid heartbeat or tremors) with minimal central nervous system side effects. They are generally used short-term for specific situations, such as performance anxiety[2][5].
- Gabapentin & Pregabalin: Originally anticonvulsants, these medications are sometimes used for anxiety and tend to have less potential for weight gain and sexual side effects, although drowsiness and dizziness may occur[3][6].
Benzodiazepines such as Xanax and Valium are very effective for short-term anxiety relief and are often cited as being well-tolerated initially. However, they carry significant risks of dependence and withdrawal, so they are not recommended for long-term use[1][2][6].
Of all these options, buspirone (Buspar) and certain SSRIs are most frequently recommended for those seeking effectiveness with minimal side effects and low risk of dependency. However, individual reactions vary, so it’s important to consult a healthcare provider to personalize your treatment and minimize side effects[1][3][7].
References
- [1] What Is The “Safest” Drug for Anxiety? – Calm Clinic
- [2] What Are Some Alternatives to Benzodiazepines for Anxiety?
- [3] What Is the Best Anxiety Medication with Less Side Effects?
- [5] 5 Non-Addictive Anxiety Medications – Washburn House
- [6] Alternatives to Benzodiazepines for Anxiety: What Works?
- [7] Which SSRIs Have the Least Side Effects? 4 Options – GoodRx