Activelle (estradiol and norethindrone) can cause a range of side effects, some more common and others rare or potentially serious[1].
Common side effects include:
- Body aches or pain
- Chills or fever
- Cold or flu-like symptoms
- Difficulty breathing
- Headache
- Itching of the vagina or genital area
- Non-menstrual vaginal bleeding
- Pain during sexual intercourse
- Thick, white vaginal discharge (may have a mild odor)
- Unusual tiredness or weakness
Other common reactions can include dizziness, stomach upset, bloating, irritability, changes in sleep patterns, nausea, weight changes, breast tenderness, or changes in sex drive and mood[5].
Serious or less common side effects that require immediate medical attention:
- Blistering, peeling, or loosening of the skin
- Breast tenderness or lump, nipple discharge
- Change in vision, double vision
- Chest pain, discomfort, or tightness
- Clay-colored stools, dark urine
- Confusion, difficulty speaking or swallowing
- Dizziness or lightheadedness, fainting
- Fast heartbeat
- Inability to move or speak, trouble walking
- Joint or muscle pain
- Nausea and vomiting, loss of appetite
- Pain or swelling in the arms, legs, jaw, back, or neck
- Redness or swelling of the breast, skin rash, hives, or itching
- Sores, ulcers, or white spots in the mouth or on the lips
- Unexpected or excess milk flow from the breasts
- Trouble recognizing objects or planning tasks
Very serious adverse effects may include heart attacks, stroke, and blood clots. Seek urgent care if you experience chest, jaw, or left arm pain, sudden severe headache, weakness on one side of the body, sudden vision changes, or swelling/pain/redness in the leg or arm[5].
Allergic reactions are rare but can include:
- Rash, itching, or swelling (especially of the face, tongue, or throat)
- Severe dizziness
- Trouble breathing
Contact your healthcare provider if you experience any side effects, especially those that are persistent, severe, or unusual[1][5].