Explain possible side effects and interaction/safety considerations for turmeric without overstating causality or efficacy.
Part of herbs, botanicals & teas side effects.
Where this page comes from
There is no SAHPRA-approved patient information leaflet for Turmeric. This page is built from SAHPRA guidance on complementary medicines, NIH LiverTox monograph on Turmeric. Retrieved 2026-09-03.
What is turmeric?
Turmeric is sold in South Africa as a complementary medicine or health supplement, not as a registered medicine with an approved leaflet.
There is no approved side-effect list for this
We checked every one of the 3,000 products in SAHPRA’s public PI/PIL repository. Turmeric is not among them, so no South African regulator has published an approved list of its side effects. That is not the same as saying it has none.
What South African regulation does and does not cover:
- Complementary medicines and health supplements are regulated in South Africa by SAHPRA as Category D medicines.
- Products already on sale keep the right to be sold while their registration application works through SAHPRA’s call-up process, so a product on a shelf today has not necessarily been assessed.
- Health supplements may only carry low-risk indications, and may only use substances and doses on SAHPRA’s published lists.
- A suspected reaction to a complementary medicine can be reported to SAHPRA in the same way as one to a prescription medicine.
Possible side effects of turmeric
No approved leaflet lists this product’s side effects. What follows is what the United States National Institutes of Health has published about it, in their words.
What it is and what it is taken for
- Turmeric (tur mer’ ik) is a widely used herbal product derived from the roots of Curcuma longa, a perennial plant belonging to the ginger family (Zingiberaceae) that is native to India but grown throughout Southern Asia and in Central America.
- Extracts of the rhizomes of turmeric contain volatile oils and curcuminoids (such as curcumin, demethoxycurcumin and others) which are believed to be the active antiinflammatory components of the herb and are often collectively referred to as curcumin.
- Curcumin comprises between 1% and 6% by dry weight of whole turmeric extracts, other components being starch, fats, proteins, fiber, vitamins, minerals, and water.
- The antiinflammatory effects of turmeric and curcumin are thought to be mediated by inhibition of leukotriene synthesis.
What has been documented about liver injury
- Both turmeric and curcumin were considered to be generally safe and for many years had not been linked to instances of liver injury in any consistent way.
- Studies of its use in various diseases showed low rates of transient and asymptomatic serum enzyme elevations during therapy, but without instances of clinically apparent acute liver injury.
- Indeed, turmeric was evaluated as a potential therapy of acute and chronic liver injury, and although its efficacy and safety were not clearly shown, therapy with turmeric and curcumin did not seem to worsen the preexisting liver conditions.
- Recently, isolated case reports and small case series of liver injury arising during use of turmeric dietary supplements have been published.
- Initially, these episodes were attributed to other exposures that might have accounted for the injury or possible contaminants in the commercial turmeric products.
- One reason given for the safety and lack of hepatotoxicity of curcumin was that it is poorly absorbed by the oral route, and it was unclear whether there was adequate systemic exposure to achieve any of the purported beneficial or adverse effects of turmeric or curcumin.
Interactions and medicines to check
Interactions happen when turmeric and something else affect each other — changing how well either works, or making side effects more likely. This includes prescription medicines, pharmacy medicines bought without a prescription, other supplements, herbal remedies and traditional medicines.
Supplements and herbal products are often assumed to be interaction-free because they are available without a prescription. That assumption is not safe. Tell your pharmacist or doctor about everything you take, including things you would not think of as medicine.
Evidence required before publish — source the following for turmeric from the SAHPRA-approved patient information leaflet or professional information, and cite what you actually used.
- Interactions named in the current approved information or authoritative monograph for turmeric
- Which interactions the source describes as requiring avoidance versus monitoring
- Any food, drink or timing interaction the source identifies
- Whether the source flags interactions with commonly used South African medicines
Bring the actual products to the conversation
A pharmacist can check for interactions much faster if they can see the packaging or a photo of it, rather than working from remembered names.
Who should use extra caution?
Who should be most careful with a product that has no approved leaflet:
- Anyone taking prescription medicine. Supplements can change how medicines work, and neither product’s leaflet will warn you, because one of them does not have a leaflet.
- Anyone on chronic medicine for HIV, TB, epilepsy, heart conditions or blood thinning, where a changed drug level matters quickly.
- Anyone who is pregnant or breastfeeding.
- Anyone with existing liver or kidney disease.
- Anyone about to have surgery.
Tell your pharmacist what you are taking
Bring the actual container. A pharmacist can check the ingredients against your prescriptions far faster from the label than from a remembered name.
Dose, timing and other factors that can affect side effects
Who should be most careful with a product that has no approved leaflet:
- Anyone taking prescription medicine. Supplements can change how medicines work, and neither product’s leaflet will warn you, because one of them does not have a leaflet.
- Anyone on chronic medicine for HIV, TB, epilepsy, heart conditions or blood thinning, where a changed drug level matters quickly.
- Anyone who is pregnant or breastfeeding.
- Anyone with existing liver or kidney disease.
- Anyone about to have surgery.
Tell your pharmacist what you are taking
Bring the actual container. A pharmacist can check the ingredients against your prescriptions far faster from the label than from a remembered name.
Serious symptoms and warning signs
Liver injury is the risk this substance has been documented for. Stop taking it and see a doctor if you notice any of these:
- Yellowing of the skin or the whites of the eyes
- Dark urine, or pale stools
- Itching all over, without a rash
- Pain in the upper right of your abdomen
- Feeling sick, losing your appetite, or unusual tiredness
What the monograph says about outcome
- Most cases of acute hepatic injury from turmeric resolve within 1 to 3 months of stopping the medication.
- In some instances, however, the injury is severe and unremitting, leading to acute liver failure and either death or need for liver transplantation.
- A severe outcome is more likely if turmeric is continued after the appearance of symptoms and signs of liver injury.
- There appears to be no cross sensitivity to hepatic injury between turmeric and other herbal products.
General warning signs that apply to anything you take
Call for emergency help now if any of these happen
- Difficulty breathing, wheezing, or tightness in the throat or chest
- Swelling of the face, lips, tongue or throat
- A widespread rash with blistering or peeling skin, or sores in the mouth, eyes or genitals
- Fainting, collapse, or a sudden severe drop in alertness
- Chest pain, or sudden weakness or numbness on one side of the body
- A fit (seizure), or confusion that comes on suddenly
In South Africa call 10177 for an ambulance, or 112 from a mobile phone. Go to your nearest emergency department if it is faster. Do not wait to see whether the symptom settles.
What to do if side effects occur
If you think you are having a side effect, the response depends on how severe it is. Use the warning signs above first — if any of those apply, treat it as urgent.
If the symptom is severe or frightening
Get medical help immediately. Call 10177 for an ambulance, or 112 from a mobile phone, or go to the nearest emergency department. Take the product and its packaging with you if you can.
If the symptom is mild but bothering you
- Write down what the symptom is, when it started, and how it relates to when you take the product
- Check the leaflet that came with the product to see whether the symptom is listed
- Speak to your pharmacist — for many questions this is the fastest route to a useful answer
- Contact the prescriber if the symptom is affecting your daily life or is not settling
Do not stop a prescribed treatment on your own
Stopping some treatments suddenly causes its own problems, and the condition being treated may get worse. If you want to stop, ask a pharmacist or doctor how to do it safely — they can usually offer an alternative.
You can also report a suspected side effect in South Africa. Reporting does not replace getting medical advice, and you do not need to be certain the product was the cause.
How to report a suspected side effect in South Africa
South Africa has an official system for reporting suspected side effects, run by the South African Health Products Regulatory Authority (SAHPRA). Reports from the public and from healthcare professionals are how safety signals get detected after a product is already in use.
Who can report
Anyone can report — you do not have to be a healthcare professional, and you do not need to prove that the product caused the problem. A suspicion is enough. Patients, caregivers and family members can all submit a report.
What to have ready
- The name of the product, its strength and form, and the batch number if you have it
- Why it was being used, and when it was started and stopped
- What the suspected reaction was, when it began, and how long it lasted
- Any other medicines, supplements or remedies being used at the same time
- Basic details about the person affected — age and sex are usually enough
How to report
SAHPRA accepts adverse reaction reports through its e-Services reporting system and through the Med Safety mobile app. Healthcare professionals can also report through the same routes. Current forms and access points are published on the SAHPRA site.
- SAHPRA Health Products Vigilance — the main vigilance and reporting hub
- SAHPRA e-Services — current adverse reaction reporting access
Reporting is not a substitute for medical care
If someone is unwell now, get medical help first and report afterwards. Urgent symptoms always take precedence over paperwork.
For a fuller walkthrough see how to report an adverse drug reaction.
Related pages
← Back to more supplement side effects.
Report a side effect
If you think you have had a side effect, you can report a suspected side effect in South Africa. Report a suspected side effect through the appropriate SAHPRA pathway where relevant.
Information only
This page gives general medicine-safety information for people in South Africa. It is not a diagnosis and not personalised medical advice. It cannot tell you whether a symptom you are having is caused by a particular product. Speak to a pharmacist or doctor about your own situation, and do not stop or change a prescribed treatment on the basis of a web page.
Editorial status: draft — not for publication
Brief SE-00514 · build rank 514 · Phase 2 · Tier 2. Every evidence slot on this page must be completed from the SAHPRA-approved source and the page signed off by a qualified clinical or pharmacy reviewer before it is published. Target length 1,300–2,000 words.