Xefo (lornoxicam) can cause side effects ranging from mild gastrointestinal disturbances to rare but serious allergic reactions and organ effects[1].
Common side effects (affecting 1 to 10 in every 100 patients) include:
- Headache and dizziness
- Nausea, abdominal pain, upset stomach
- Diarrhoea and vomiting
[1][3][5]
Uncommon side effects (affecting 1 to 10 in every 1,000 patients) may occur:
- Weight loss (anorexia), insomnia, depression
- Eye discharge (conjunctivitis), ringing in the ears (tinnitus)
- Irregular heartbeat, rapid heart rate, flushing
- Constipation, excessive wind (flatulence), belching, dry mouth, gastritis, peptic ulcer, upper abdominal pain, mouth ulcers
- Increased liver function tests, malaise
- Rash, itching, increased sweating, redness of skin, rapid skin swelling (angioedema), hives (urticaria), oedema
- Pain in the joints (arthralgia)
[1][3]
Rare side effects (affecting 1 to 10 in every 10,000 patients) include:
- Sore throat, anaemia, reduced blood cell counts
- Allergic reactions (anaphylaxis), confusion, nervousness, agitation, drowsiness
- High blood pressure, hot flushes, bleeding or bruising easily
- Difficulty breathing, bronchospasm
- Perforated ulcer, gastrointestinal bleeding, black stools, vomiting of blood
- Inflammation in the mouth or oesophagus
- Bone pain, muscle cramps, muscle pain
- Urinary disturbances or increased blood urea/creatinine
[1][3]
Very rare side effects (less than 1 in 10,000 patients):
- Liver problems including hepatitis, liver damage, jaundice, cholestasis
- Severe skin disorders such as Stevens-Johnson syndrome or toxic epidermal necrolysis
- Aseptic meningitis
- Severe anemia subtypes and kidney toxicity
[1][3]
As with other NSAIDs, there may be a small increased risk of heart attack or stroke. Severe hypersensitivity reactions, significant gastrointestinal symptoms, sudden skin reactions (like blisters or widespread rash), severe jaundice, or breathing/swelling issues require immediate discontinuation and urgent medical attention[1][3].
Specific rare syndromes such as DRESS (Drug Reaction with Eosinophilia and Systemic Symptoms) and serious skin reactions have been reported, sometimes with fatal outcomes[3].
Always consult a healthcare professional regarding side effects, and report any unusual symptoms promptly.