Side Effects

Premarin 0.625 Side Effects

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Side Effects

Premarin 0.625 (conjugated estrogens) is associated with a range of side effects, both common and serious. Patients should discuss any concerning symptoms with their healthcare provider.

Common side effects include:

  • Stomach pain, cramps, bloating, gas, nausea, or vomiting[1][5]
  • Headache[1][3]
  • Back or leg pain[1][3][5]
  • Feeling unusually weak or tired[1]
  • Breast pain or tenderness[1][2][3]
  • Vaginal discharge, irritation, or yeast infection[1][3][5]
  • Irregular or breakthrough vaginal bleeding, spotting[1][2][3]
  • Hair loss[1][6]
  • Fluid retention (edema, swelling)[1][3][4]
  • Trouble sleeping[1][3]
  • Depression and mood changes[1][3][5]
  • Loss of scalp hair or increase in facial hair[5]

Less common or rare side effects can include:

  • Vaginal infections or itching[3][5]
  • Patchy skin discoloration (melasma)[2][5]
  • Changes in sexual desire[2][5]
  • Contact lens intolerance[2]
  • Increased blood pressure or triglycerides[2]
  • Gallbladder disease[2][3]
  • Jaundice or liver problems[2][4]

Serious side effects (seek immediate medical attention):

  • Severe allergic reactions (swelling, rash, difficulty breathing)[1][4]
  • Signs of blood clots (sudden leg/arm pain, chest pain, shortness of breath, vision changes)[1][2][3][4]
  • Signs of stroke (sudden numbness, weakness, confusion, vision/speech problems)[4]
  • Heart attack symptoms (chest pain or pressure, pain radiating to jaw or shoulder, sweating)[4]
  • Unusual vaginal bleeding, pelvic pain, breast lumps[4][5][7]
  • Memory problems, confusion, unusual behavior[4]

Long-term or boxed warnings:

  • Increased risk of blood clots, heart attack, and stroke[3]
  • Increased risk of breast cancer and uterine cancer (if taken without a progestin)[3]
  • Possible increased risk of dementia for women over 65[3]

It is not always possible to predict who will experience side effects or which ones will occur. Patients should contact their healthcare provider if any symptoms are bothersome, persist, or worsen.

References

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