Afaris FC 300/150 contains rifampicin 300mg and isoniazid 150mg, used together to treat tuberculosis. The most common side effects include nausea, vomiting, loss of appetite, diarrhea, stomach discomfort, and a noticeable orange or red color to urine, sweat, saliva, or tears[3][8].
Other frequently observed adverse effects are:
- Headache
- Constipation
- Skin flushing or itching
- Dry mouth
- Breast enlargement in men
- Acne
- Irregular periods
- Increased thirst and tiredness (possible high blood sugar)
- Inflammation of blood vessels
Serious side effects may include:
- Yellowing of skin or eyes (jaundice)
- Severe skin rash or itching
- Difficulty breathing or wheezing
- Fever, chills, headache, or dizziness
- Joint pain and swelling
- Shortness of breath and cough
- Bone pain
- Mental depression, confusion, or mood changes
- Numbness, tingling, or burning pain in hands and feet
- Unusual bleeding or bruising
- Dark urine, light-colored stools
- Persistent loss of appetite, weight loss
- Convulsions
These serious side effects require immediate medical attention[5][8].
Some uncommon reactions can include pellagra (Vitamin B3 deficiency, presenting with diarrhea, dermatitis, and dementia), worsening tuberculosis symptoms (with fever, fatigue, night sweats, and swollen lymph nodes), and pancreatitis (severe abdominal and back pain)[5].
The coloration of body fluids is a harmless side effect, but can permanently stain soft contact lenses[3]. If you notice any signs of allergy (rash, swelling, trouble breathing) or jaundice, consult your healthcare provider promptly[5][8].